By plane
The Wheeling-Ohio County Airport is located eight miles north of downtown Wheeling, off of WV Route 2. Though this airport is open for public use, no commercial airlines service it. The closest commercial service is located at Pittsburgh International Airport, which is approximately 40 miles northeast of Wheeling in Western Pennsylvania.
By car
Interstate 70 is the primary route for reaching Wheeling from the east or west. Travelers in Northern Ohio and Western Pennsylvania can reach Wheeling via OH Route 7 or WV Route 2. Wheeling can be reached from Southern Ohio and Southern West Virginia via WV Route 2, or Interstate 79 and Interstate 77 for points further south. U.S. Route 250, U.S. Route 40, and WV Route 88 are other major highways that pass through Wheeling.